Year: 2017

Thank you for watching this video. The following is a list of links to materials documenting the data presented in this video.

Fluoroquinolones damage mammalian mitochondrial DNA via Topoisomerase II:

http://molpharm.aspetjournals.org/content/50/5/1178.long

This article states “These results suggest that ciprofloxacin may be causing cytotoxicity by interfering with a mitochondrial topoisomerase II”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760005/

This article states “quinolones target bacterial gyrases (34) and mtDNA topoisomerases (15),”

Quinolones and damage mammalian mitochondrial DNA:

https://www.dev.myquinstory.info/wp-content/uploads/2010/01/Castora-DNA-Synthesis-In-mam-mtDNA-1983.pdf

FDA’s April 27, 2013 Pharmacovigilance Review, where the FDA notes that the mechanism for action through which fluoroquinolones induce peripheral neuropathy is mitochondrial toxicity. 

Pharmacovigilance Review

Fluoroquinolones as adjunct to chemotherapy:

http://infectagentscancer.biomedcentral.com/articles/10.1186/1750-9378-7-33

http://www.nature.com/bjc/journal/v95/n8/full/6603355a.html

https://www.ncbi.nlm.nih.gov/pubmed/10414727
Fluoroquinolone based chemotherapy agents:

https://pubmed.ncbi.nlm.nih.gov/28504025/

Antitumor Power of The Quinolone Antibiotics

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997924/

Article states “quinolones having significant potency against eukaryotic Type II topoisomerases (topo II)”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745469

Ubiquitous Nature of Fluoroquinolones: The Oscillation between Antibacterial and Anticancer Activities

Fluoroquinolones described as chemotherapy

http://pharmaxchange.info/press/2011/05/mechanism-of-action-of-quinolones-and-fluoroquinolones/

“Late Effects” of chemotherapy

http://www.cancer.net/survivorship/long-term-side-effects-cancer-treatment

http://www.mayoclinic.org/diseases-conditions/cancer/in-depth/cancer-survivor/art-20045524

http://ww5.komen.org/BreastCancer/LongTermSideEffectsofChemotherapy.html